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Djelovanje kurkumina – pregled kliničkih ispitivanja

Pregled kliničkih ispitivanja Odjek.press prenosi od stručnjaka koji vode   https://www.kurkumin.hr/ 

info@kurkumin.hr je mail za dodatne upite a osobno se u prostoru Multiplex digitald.o.o. – Tehnopolis, Savska 41, u Zagrebu može kupiti proizvod koji je sigurno najdjelotvorniji dodatak prehrani zasnovan na čistom kurkuminu, ili zovite 01/6177-144.

Liječnički tim od 3 doktora znanosti potvrdio je CurcuONE kao trenutno najkvalitetniji pripravak kurkumina, te ga preporuča svima koji su odlučili poboljšati svoje zdravlje kurkuminom.

 

Alergijske bolesti

Alergijski dermatitis kao posljedica alergije na hranu 1

Alergijski rinitis 2

 

Bolesti srca i krvnih žila

Prevencija srčanog infarkta i ateroskleroze3

Srčano zatajenje 4

Prevencija moždanog udara 5

 

Bolesti jetre

Nealkoholni steatohepatitis (masna jetra) 6

Virusni hepatitis 7

Oštećenje jetre uzrokovano alkoholom 8

 

Bolesti probavnog sustava

Želučani ulkus9

Gastritis i dispepsija  (GERB) 10

Sindrom iritabilnog crijeva 11,12

Upalne bolesti crijeva (Crohnova bolest i ulcerozni kolitis) 13,14

Prevencija nastanka žučnih kamenaca 15

 

Imunološki sustav

Jačanje imunološkog sustava 16

Brojne autoimune bolesti 17

 

Kožne bolesti

Psorijaza 18

Kronični svrbež 19

Dermatitis kao posljedica reakcije na hranu 1

 

Metaboličke bolesti, šećerna bolest, hiperlipidemija

Hiperlipoproteinemija (povišene masnoće) 20

Hiperuricemija (povišeni urati u krvi) 20

Predijabetes i inzulinska rezistencija (prevencija šećerne bolesti) 21

Komplikacije debljine 22

Komplikacije šećerne bolesti 2324

 

Plućne bolesti

Bronhalna astma 25

 

Psihičko zdravlje i kognitivna funkcija

Pomoć pri koncentraciji 26,27

Staračka demencija 26

Depresija 28

Alzheimerova bolest 29

 

Sport

Oštećenje mišića nakon intenzivnog vježbanja („muskulfiber“)30

 

Zdravlje muškaraca

Erektilna disfunkcija 31

 

Zdravlje žena

Perimenstrualne tegobe 32

Postmenopauzalne tegobe 33

 

Zglobovi i mišići

Reumatoidni artritis 34

Osteoartritis (bolovi u zglobovima)3536

 

Zloćudne bolesti

Prevencija karcinoma debelog crijeva 37

Smanjenje broja polipa debelog crijeva 38

Prevencija i pomoć u liječenju karcinoma prostate 39

Prevencija i pomoć u liječenju karcinoma dojke 40

Smanjivanje simptoma tijekom kemoterapije i radioterapije 41

 

Reference:

 

  1. Shin HS, See H-J, Jung SY, et al. Turmeric (Curcuma longa) attenuates food allergy symptoms by regulating type 1/type 2 helper T cells (Th1/Th2) balance in a mouse model of food allergy. J Ethnopharmacol. 2015;175:21-29. doi:10.1016/j.jep.2015.08.038
  2. Wu S, Xiao D. Effect of curcumin on nasal symptoms and airflow in patients with perennial allergic rhinitis. Ann Allergy, Asthma Immunol. 2016;117(6):697-702.e1. doi:10.1016/j.anai.2016.09.427
  3. Jiang S, Han J, Li T, et al. Curcumin as a potential protective compound against cardiac diseases. Pharmacol Res. 2017;119:373-383. doi:10.1016/j.phrs.2017.03.001
  4. Saeidinia A, Keihanian F, Butler AE, Bagheri RK, Atkin SL, Sahebkar A. Curcumin in heart failure: A choice for complementary therapy? Pharmacol Res. 2018;131:112-119. doi:10.1016/j.phrs.2018.03.009
  5. Liu Z, Ran Y, Huang S, et al. Curcumin Protects against Ischemic Stroke by Titrating Microglia/Macrophage Polarization. Front Aging Neurosci. 2017;9:233. doi:10.3389/fnagi.2017.00233
  6. Rahmani S, Asgary S, Askari G, et al. Treatment of Non-alcoholic Fatty Liver Disease with Curcumin: A Randomized Placebo-controlled Trial. Phyther Res. 2016;30(9):1540-1548. doi:10.1002/ptr.5659
  7. Wei Z-Q, Zhang Y-H, Ke C-Z, et al. Curcumin inhibits hepatitis B virus infection by down-regulating cccDNA-bound histone acetylation. World J Gastroenterol. 2017;23(34):6252-6260. doi:10.3748/wjg.v23.i34.6252
  8. Nanji AA, Jokelainen K, Tipoe GL, Rahemtulla A, Thomas P, Dannenberg AJ. Curcumin prevents alcohol-induced liver disease in rats by inhibiting the expression of NF-κB-dependent genes. Am J Physiol Liver Physiol. 2003;284(2):G321-G327. doi:10.1152/ajpgi.00230.2002
  9. Khonche A, Biglarian O, Panahi Y, et al. Adjunctive Therapy with Curcumin for Peptic Ulcer: a Randomized Controlled Trial. Drug Res (Stuttg). 2016;66(08):444-448. doi:10.1055/s-0042-109394
  10. Judaki A, Rahmani A, Feizi J, Asadollahi K, Hafezi Ahmadi MR. CURCUMIN IN COMBINATION WITH TRIPLE THERAPY REGIMES AMELIORATES OXIDATIVE STRESS AND HISTOPATHOLOGIC CHANGES IN CHRONIC GASTRITIS-ASSOCIATED HELICOBACTER PYLORI INFECTION. Arq Gastroenterol. 54(3):177-182. doi:10.1590/S0004-2803.201700000-18
  11. Portincasa P, Bonfrate L, Scribano MLL, et al. Curcumin and Fennel Essential Oil Improve Symptoms and Quality of Life in Patients with Irritable Bowel Syndrome. J Gastrointestin Liver Dis. 2016;25(2):151-157. http://www.ncbi.nlm.nih.gov/pubmed/27308645. Accessed August 5, 2018.
  12. Bundy R, Walker AF, Middleton RW, Booth J. Turmeric Extract May Improve Irritable Bowel Syndrome Symptomology in Otherwise Healthy Adults: A Pilot Study. J Altern Complement Med. 2004;10(6):1015-1018. doi:10.1089/acm.2004.10.1015
  13. Cunha Neto F, Marton LT, de Marqui SV, Lima TA, Barbalho SM. Curcuminoids from Curcuma Longa : New adjuvants for the treatment of crohn’s disease and ulcerative colitis? Crit Rev Food Sci Nutr. March 2018:1-8. doi:10.1080/10408398.2018.1456403
  14. Lang A, Salomon N, Wu JCY, et al. Curcumin in Combination With Mesalamine Induces Remission in Patients With Mild-to-Moderate Ulcerative Colitis in a Randomized Controlled Trial. Clin Gastroenterol Hepatol. 2015;13(8):1444-9.e1. doi:10.1016/j.cgh.2015.02.019
  15. Yang F, Tang X, Ding L, et al. Curcumin protects ANIT-induced cholestasis through signaling pathway of FXR-regulated bile acid and inflammation. Sci Rep. 2016;6:33052. doi:10.1038/srep33052
  16. Jagetia GC, Aggarwal BB. “Spicing Up” of the Immune System by Curcumin. J Clin Immunol. 2007;27(1):19-35. doi:10.1007/s10875-006-9066-7
  17. Bright JJ. CURCUMIN AND AUTOIMMUNE DISEASE. In: The Molecular Targets and Therapeutic Uses of Curcumin in Health and Disease. Vol 595. Boston, MA: Springer US; 2007:425-451. doi:10.1007/978-0-387-46401-5_19
  18. Antiga E, Bonciolini V, Volpi W, Del Bianco E, Caproni M. Oral Curcumin (Meriva) Is Effective as an Adjuvant Treatment and Is Able to Reduce IL-22 Serum Levels in Patients with Psoriasis Vulgaris. Biomed Res Int. 2015;2015:283634. doi:10.1155/2015/283634
  19. Pakfetrat M, Basiri F, Malekmakan L, Roozbeh J. Effects of turmeric on uremic pruritus in end stage renal disease patients: a double-blind randomized clinical trial. J Nephrol. 2014;27(2):203-207. doi:10.1007/s40620-014-0039-2
  20. Panahi Y, Kianpour P, Mohtashami R, Jafari R, Simental-Mendía LE, Sahebkar A. Curcumin Lowers Serum Lipids and Uric Acid in Subjects With Nonalcoholic Fatty Liver Disease. J Cardiovasc Pharmacol. 2016;68(3):223-229. doi:10.1097/FJC.0000000000000406
  21. Chuengsamarn S, Rattanamongkolgul S, Luechapudiporn R, Phisalaphong C, Jirawatnotai S. Curcumin extract for prevention of type 2 diabetes. Diabetes Care. 2012;35(11):2121-2127. doi:10.2337/dc12-0116
  22. Ghazimoradi M, Saberi-Karimian M, Mohammadi F, et al. The Effects of Curcumin and Curcumin-Phospholipid Complex on the Serum Pro-oxidant-Antioxidant Balance in Subjects with Metabolic Syndrome. Phyther Res. 2017;31(11):1715-1721. doi:10.1002/ptr.5899
  23. Yang F, Yu J, Ke F, et al. Curcumin Alleviates Diabetic Retinopathy in Experimental Diabetic Rats. Ophthalmic Res. 2018;60(1):43-54. doi:10.1159/000486574
  24. Appendino G, Belcaro G, Cornelli U, et al. Potential role of curcumin phytosome (Meriva) in controlling the evolution of diabetic microangiopathy. A pilot study. Panminerva Med. 2011;53(3 Suppl 1):43-49. http://www.ncbi.nlm.nih.gov/pubmed/22108476. Accessed August 5, 2018.
  25. Abidi A, Gupta S, Agarwal M, Bhalla HL, Saluja M. Evaluation of Efficacy of Curcumin as an Add-on therapy in Patients of Bronchial Asthma. J Clin Diagn Res. 2014;8(8):HC19-24. doi:10.7860/JCDR/2014/9273.4705
  26. Small GW, Siddarth P, Li Z, et al. Memory and Brain Amyloid and Tau Effects of a Bioavailable Form of Curcumin in Non-Demented Adults: A Double-Blind, Placebo-Controlled 18-Month Trial. Am J Geriatr Psychiatry. 2018;26(3):266-277. doi:10.1016/J.JAGP.2017.10.010
  27. Noorafshan A, Karimi F, Kamali A-M, Karbalay-Doust S, Nami M. Restorative effects of curcumin on sleep-deprivation induced memory impairments and structural changes of the hippocampus in a rat model. Life Sci. 2017;189:63-70. doi:10.1016/j.lfs.2017.09.018
  28. Ng QX, Koh SSH, Chan HW, Ho CYX. Clinical Use of Curcumin in Depression: A Meta-Analysis. J Am Med Dir Assoc. 2017;18(6):503-508. doi:10.1016/j.jamda.2016.12.071
  29. Reddy PH, Manczak M, Yin X, et al. Protective effects of a natural product, curcumin, against amyloid β induced mitochondrial and synaptic toxicities in Alzheimer’s disease. J Investig Med. 2016;64(8):1220-1234. doi:10.1136/jim-2016-000240
  30. Davis JM, Murphy EA, Carmichael MD, et al. Curcumin effects on inflammation and performance recovery following eccentric exercise-induced muscle damage. Am J Physiol Integr Comp Physiol. 2007;292(6):R2168-R2173. doi:10.1152/ajpregu.00858.2006
  31. Abdel Aziz MT, Rezq AM, Atta HM, et al. Molecular signalling of a novel curcumin derivative versus Tadalafil in erectile dysfunction. Andrologia. 2015;47(6):616-625. doi:10.1111/and.12309
  32. Khayat S, Fanaei H, Kheirkhah M, Moghadam ZB, Kasaeian A, Javadimehr M. Curcumin attenuates severity of premenstrual syndrome symptoms: A randomized, double-blind, placebo-controlled trial. Complement Ther Med. 2015;23(3):318-324. doi:10.1016/j.ctim.2015.04.001
  33. Akazawa N, Choi Y, Miyaki A, et al. Curcumin ingestion and exercise training improve vascular endothelial function in postmenopausal women. Nutr Res. 2012;32(10):795-799. doi:10.1016/j.nutres.2012.09.002
  34. Chandran B, Goel A. A Randomized, Pilot Study to Assess the Efficacy and Safety of Curcumin in Patients with Active Rheumatoid Arthritis. Phyther Res. 2012;26(11):1719-1725. doi:10.1002/ptr.4639
  35. Kuptniratsaikul V, Thanakhumtorn S, Chinswangwatanakul P, Wattanamongkonsil L, Thamlikitkul V. Efficacy and Safety of Curcuma domestica Extracts in Patients with Knee Osteoarthritis. J Altern Complement Med. 2009;15(8):891-897. doi:10.1089/acm.2008.0186
  36. Daily JW, Yang M, Park S. Efficacy of Turmeric Extracts and Curcumin for Alleviating the Symptoms of Joint Arthritis: A Systematic Review and Meta-Analysis of Randomized Clinical Trials. J Med Food. 2016;19(8):717-729. doi:10.1089/jmf.2016.3705
  37. Johnson JJ, Mukhtar H. Curcumin for chemoprevention of colon cancer. Cancer Lett. 2007;255(2):170-181. doi:10.1016/j.canlet.2007.03.005
  38. Carroll RE, Benya R V., Turgeon DK, et al. Phase IIa Clinical Trial of Curcumin for the Prevention of Colorectal Neoplasia. Cancer Prev Res. 2011;4(3):354-364. doi:10.1158/1940-6207.CAPR-10-0098
  39. Teiten M-H, Gaascht F, Eifes S, Dicato M, Diederich M. Chemopreventive potential of curcumin in prostate cancer. Genes Nutr. 2010;5(1):61-74. doi:10.1007/s12263-009-0152-3
  40. Banik U, Parasuraman S, Adhikary AK, Othman NH. Curcumin: the spicy modulator of breast carcinogenesis. J Exp Clin Cancer Res. 2017;36(1):98. doi:10.1186/s13046-017-0566-5
  41. Belcaro G, Hosoi M, Pellegrini L, et al. A Controlled Study of a Lecithinized Delivery System of Curcumin (Meriva®) to Alleviate the Adverse Effects of Cancer Treatment. Phyther Res. 2014;28(3):444-450. doi:10.1002/ptr.5014

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